Copyright © 1996, 2001 by Galen Daryl Knight and VitaleTherapeutics, Inc.

Base Structure of Activated Calichemicins and Esperamicins

The cores of active metabolites of calichemicins (shown below left) and esperamicins, groups of cytotoxic anti-cancer agents under development through the combined efforts of several pharmaceutical companies, have carbamate and sulfur moieties in common with the much simpler vitaletheine (below right). The prodrugs actually become more similar to vitaletheine as they are "activated".
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